In the design of Hydraulic Manifold Blocks (HMB), dynamic performance of inner pipeline networks usually should be evaluated.To meet the design requirements, dynamic characteristic simulation is often needed.Based on comprehensive study on the existing simulation methods, a new method combined of Power Bond Graph(PBG) and Computational Fluid Dynamic (CFD) is proposed.In this method, flow field of typical channels inside HMB is analyzed with CFD to obtain the local resistance coefficients.Then, with these coefficients, a new sectional lumped-parameter model including kinetic friction factor is developed using PBG.A typical HMB design example is given and the comparison between the simulation and the experimental results demonstrates the feasibility and effectiveness of the proposed method.