目的对比分析外科修补术与介入封堵术治疗继发孔型房间隔缺损的疗效。方法将2008年3月-2011年5月期间我院收治的180例继发孔型房间隔缺损患者按治疗方式分为观察组(n=97)与对照组(n=83),观察组患者接受外科修补术,对照组患者接受介入封堵术。所有患者在治疗结束后接受为期12个月的随访,对比分析两组疗效。结果①观察组手术成功率显著高于对照组,差异有统计学意义(P<0.05)。②观察组手术时间、术后住院时间显著高于对照组,住院费用显著低于对照组,差异有统计学意义(P<0.05)。③观察组并发症发生率显著高于对照组,差异有统计学意义(P<0.05)。结论外科修补术与介入封堵术治疗继发孔型房间隔缺损各有其特点,外科修补术手术成功率较高,介入封堵术的术后住院时间短,住院费用低,并且较少发生并发症。 Objective To compare the curative effect of surgical repair and interventional closure in the treatment of atrial septal defect with secondary access. Methods A total of 180 patients with ASD treated in our hospital from March 2008 to May 2011 were divided into observation group (n = 97) and control group (n = 83) Underwent surgical repair, patients in the control group received interventional occlusion. All patients received a 12-month follow-up after the end of treatment, and compared the efficacy of the two groups. Results ① The success rate of operation in observation group was significantly higher than that in control group, with significant difference (P <0.05). ② The operation time and postoperative hospital stay in the observation group were significantly higher than those in the control group, and the hospitalization expenses were significantly lower than those in the control group (P <0.05). ③ The incidence of complications in the observation group was significantly higher than that in the control group, the difference was statistically significant (P <0.05). Conclusion Surgical repair and interventional closure have their own characteristics in the treatment of atrial septal defect secondary to perforation. Surgical repair has a high success rate of operation, shorter postoperative hospitalization time, lower hospitalization cost and less incidence of postoperative occlusion complication.