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目的观察唐力(那格列奈)对初发2型糖尿病的疗效。方法50例(男28例,女22例)初发2型糖尿病,年龄32～71(50±10.1)岁,在常规治疗(饮食控制+运动)基础上,给予唐力60mg,3次/天,进餐前20分钟服用,对空腹血糖>10.0mmol/L者,加用二甲双胍250mg,3次/天,餐后服用,疗效不佳者将唐力加量至120mg,3次/天,观察12周。结果治疗后空腹及餐后血糖、糖化血红蛋白均明显下降(P<0.01);胰岛素分泌高峰前移,曲线下面积总量减少(P<0.01);甘油三脂有所下降,但差别无统计学意义(P>0.05);体重指数、总胆固醇均无明显变化(P>0.05)。结论唐力具有有效控制初发2型糖尿病患者空腹及餐后血糖的作用,同时可以恢复胰岛素分泌的正常生理模式,且副作用小,应用较安全,无体重增加的作用。
Objective To observe the effect of Tangli (nateglinide) on newly diagnosed type 2 diabetes mellitus. Methods Fifty patients (28 males and 22 females) with type 2 diabetes mellitus were enrolled in this study. Their age ranged from 32 to 71 years (50 ± 10.1) years old. On the basis of routine treatment (diet control + exercise) , Taking 20 minutes before eating, fasting blood glucose> 10.0mmol / L were added metformin 250mg, 3 times / day, after taking meal, the effect is not good, the amount of Tang Li added to 120mg, 3 times / day, observation 12 week. Results The fasting and postprandial blood glucose and HbA1c were significantly decreased (P <0.01), the peak of insulin secretion was advanced and the area under the curve was decreased (P <0.01), but the triglyceride was decreased, but the difference was not statistically significant Significance (P> 0.05); body mass index, total cholesterol had no significant change (P> 0.05). Conclusion Tang force can effectively control the fasting and postprandial blood glucose in patients with newly diagnosed type 2 diabetes mellitus, and restore the normal physiological model of insulin secretion with less side effects and safer, no weight gain.