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腹腔注射内毒素所致大鼠急性内毒素血症时肝组织、肝细胞及肝枯否氏细胞内ＰＡＦ含量显著升高，肝枯否氏细胞培养上清液中ＰＡＦ含量也显著升高，但肝细胞培养上清液中ＰＡＦ未见明显升高，并见肝组织ＭＤＡ明显增加，ＡＴＰ显著降低。银杏内酯Ｂ５ｍｇ／ｋｇ于攻毒前１５分钟ｉｐ可显著提高肝组织ＡＴＰ的含量，降低ＭＤＡ的水平，但不影响ＰＡＦ的升高。表明ＰＡＦ可能是内毒素血症时肝功能损害的重要介质之一，枯否氏细胞可能是肝内ＰＡＦ的主要来源，银杏内酯Ｂ可能是一个内毒素休克时有价值的侯选治疗药物。
In acute endotoxemia induced by intraperitoneal injection of endotoxin, the PAF content in liver tissue, hepatocytes, and liver Kupffer cells increased significantly, but the PAF content in liver Kupffer cell culture supernatants also increased significantly. No significant elevation of PAF in the supernatant of hepatocyte cultures was observed, and MDA in the liver tissue was significantly increased, and ATP was significantly reduced. Ginkgolide B5mg/kg 15 minutes before challenge can significantly increase the ip content of liver tissue, reduce the level of MDA, but does not affect the increase of PAF. It is suggested that PAF may be one of the important mediators of liver function damage in endotoxemia, Kupffer cells may be the main source of PAF in liver, and ginkgolide B may be a valuable candidate drug for endotoxin shock.