In China, directly dropping high temperature refrigerant into conventional com- pressor is considered as a dominant technical route for development of moderately high temperature heat pump. Based on this route, selection criteria for high tem- perature refrigerant were presented with consideration of several influencing fac- tors. Moreover, a set of research methods were built including theoretical calcula- tions and experimental tests. Four high temperature refrigerants from HTR01 to HTR04 were compared and analyzed. In results, firstly, HTR03 and HTR04 belonging to non-ozone depleting refrigerants could bring outstanding environmental benefits; secondly, the condenser outlet water efficiently generated by heat pump using high temperature refrigerants could cover 60℃―90℃; finally, the feasibility of the tech- nical route and the research methods were proved. In China, directly dropping high temperature refrigerant into conventional com- pressor is considered as a dominant technical route for development of moderately high temperature heat pump. Based on this route, selection criteria for high tem- perature refrigerant were presented with several influencing facs - tors. Moreover, a set of research methods were built including theoretical calcula- tions and experimental tests. Four high temperature refrigerants from HTR01 to HTR04 were compared and analyzed. In results, first, HTR03 and HTR04 belong to non-ozone depleting refrigerants could secondly, the condenser outlet water efficiently generated by heat pump using high temperature refrigerants can cover 60 ° C-90 ° C; finally, the feasibility of the tech- nical route and the research methods were proved.