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目的:研究层粘连蛋白(Laminin,LN)在口腔疣状癌中的表达,探讨其在口腔疣状癌发生发展中的作用。方法:取15例口腔疣状癌、10例正常口腔黏膜、20例口腔鳞癌(高、低分化鳞癌各10例),应用免疫组织化学SP法检测上述标本中LN的表达和分布。结果:口腔疣状癌组织中层粘连蛋白阳性表达率为40%,明显高于高分化鳞癌(20%)和低分化鳞癌(0%);口腔疣状癌、高分化鳞癌、低分化鳞癌组织中层粘连蛋白的表达均低于正常口腔黏膜组织(100%)。结论:层粘连蛋白可能在口腔疣状癌的浸润与转移过程中起重要作用。
Objective: To investigate the expression of laminin (LN) in oral wart carcinoma and its role in the development of oral verrucous carcinoma. Methods: Fifteen cases of oral verrucous carcinoma, 10 cases of normal oral mucosa and 20 cases of oral squamous cell carcinoma (10 cases of high and poorly differentiated squamous cell carcinoma) were enrolled. The expression and distribution of LN in these specimens were detected by immunohistochemical SP method. Results: The positive rate of laminin in oral verrucous carcinoma was 40%, which was significantly higher than that in well-differentiated squamous cell carcinoma (20%) and poorly differentiated squamous cell carcinoma (0%). Oral verrucous carcinoma, well differentiated squamous cell carcinoma, poorly differentiated The expression of laminin in squamous cell carcinoma was lower than that of normal oral mucosa (100%). Conclusion: Laminin may play an important role in the invasion and metastasis of oral verrucous carcinoma.