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本文报导了螺旋包结络合物对N-烷基-3-羟基吡啶羧酸酯催化水解的特殊微环境效应。合成的受物为N-甲基3-羟基吡啶乙酸酯碘化物1;N-八烷基3-羟基吡啶乙酸酯碘化物2;N-十二烷基3-羟基吡啶乙酸酯3;N-甲基3-羟基吡啶十二酸酯碘化物4。所有受物的自发水解和加入一定浓度的羧甲基糖淀粉钠5的催化水解反应都遵循一级反应动力学。受物3和4的k_(obs)随5的加入呈现Michaelis-Menten饱和动力学型式。分别研究了NaCl存在和不存在时,加入5对受物3水解反应的影响,肯定了所形成的络合物系羧甲基糖淀粉钠与受物生成的螺旋包结物。从受物3的k_(obs)的温度依赖性求出了螺旋包结络合物水解反应的活化焓和活化熵,并与相
In this paper, we report the special microenvironmental effects of helical inclusion complexes on the catalytic hydrolysis of N-alkyl-3-hydroxypicolinate. The synthesized receptors were N-methyl 3-hydroxypyridine acetate iodide 1; N-octaalkyl 3-hydroxypyridine acetate iodide 2; N-dodecyl 3-hydroxypyridine acetate 3 ; N-methyl 3-hydroxypicolinate iodide 4. The spontaneous hydrolysis of all the receptors and the addition of a certain concentration of sodium carboxymethyl starch glycolate 5 catalyzed hydrolysis reactions follow the first-order reaction kinetics. The Michaelis-Menten saturation kinetic patterns of k_ (obs) for Acceptors 3 and 4 with 5 additions. The effect of 5 on the hydrolysis of acceptor 3 was studied respectively in the presence and absence of NaCl, and the formation of a spiral inclusion complex with sodium carboxymethyl starch glycolate and its receptor was confirmed. The activation enthalpy and activation entropy of the hydrolysis reaction of helical inclusion complex were calculated from the temperature dependency of k obs of the receptor 3,