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目的观察节律性化疗联合根治性放疗治疗恶性肿瘤的疗效及不良反应。方法 86例恶性肿瘤患者随机分成两组,观察组行节律性化疗联合根治性放疗,对照组行单纯根治性放疗。两组同一病种患者放疗方式及剂量基本相同,常规每周5次,每次2Gy/DT。放疗总剂量:食道癌68-72Gy,鼻咽癌69-74Gy,非霍奇金淋巴瘤42-46Gy,非小细胞肺癌60-66Gy。化疗采用DDP10mg/次,3次/周,每周2、4、6进行化疗。结果观察组有效率为69.8%;对照组效率为39.5%,两组有效率的差异有统计学意义(P<0.05)。观察组生活质量改善31(72.1%);对照组生活质量改善18例(41.9%),两组生活质量改善率的差异有统计学意义(P<0.05)。两组不良反应率无统计学差异。结论节律性化疗联合根治性放疗疗效明显优于单纯根治性放疗,且不良反应无明显增加。
Objective To observe the curative effect and adverse reactions of rhythm chemotherapy combined with radical radiotherapy for malignant tumors. Methods 86 patients with malignant tumor were randomly divided into two groups. The observation group was treated with rhythmic chemotherapy combined with radical radiotherapy, and the control group was treated with radical curative radiotherapy. The radiation therapy and dose of the two groups of patients with the same disease were basically the same, routinely 5 times a week, each time 2Gy/DT. The total dose of radiotherapy: 68-72 Gy of esophageal cancer, 69-74 Gy of nasopharyngeal carcinoma, 42-46 Gy of non-Hodgkin’s lymphoma, and 60-66 Gy of non-small cell lung cancer. Chemotherapy was performed with DDP 10 mg/time, 3 times/week, and chemotherapy was performed on 2, 4, and 6 weeks. Results The effective rate was 69.8% in the observation group and 39.5% in the control group. There was a statistically significant difference between the two groups (P<0.05). The quality of life in the observation group was improved by 31 (72.1%); in the control group, the quality of life was improved by 18 cases (41.9%). There was a statistically significant difference in the quality of life improvement between the two groups (P<0.05). There was no statistical difference in adverse reaction rates between the two groups. Conclusion The curative effect of rhythmical chemotherapy combined with radical radiotherapy is superior to that of radical radiotherapy alone, and there is no significant increase in adverse reactions.