前列腺素(PGs)是一类具有高度生物活性的脂质的总称,首次由von Euler报告。PGs的前体是花生四烯酸(AA),免疫系统的各种细胞均可代谢花生四烯酸而生成PGs。实验结果表明,在添加促细胞分裂剂或抗原刺激的培养液中的白细胞,可以合成并释放前列腺素E_1(PGE_1)。巨噬细胞被激活后释放的PGs,被认为是免疫反应中PGs的主要来源。事实上,免疫活性细胞对于PGs的作用是十分敏感的。许多实验已证实,PGs是一种重 Prostaglandins (PGs) are a group of highly biologically active lipids, first reported by von Euler. The precursors of PGs are arachidonic acid (AA), and various cells of the immune system can metabolize arachidonic acid to produce PGs. The experimental results show that prostaglandin E_1 (PGE_1) can be synthesized and released by adding leukocytes in cytokines or antigen-stimulated culture medium. PGs released after the activation of macrophages are considered as the main source of PGs in the immune response. In fact, the effect of immunocompetent cells on PGs is very sensitive. Many experiments have confirmed that PGs is a heavy