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肝纤维化是Ⅰ，Ⅲ型胶原为主的细胞外基质（ｅｘｔｒａｃｅｌｌｕｌａｒｍａｔｒｉｘ，ＥＣＭ）成分过度沉积导致的病理性疾病．基质金属蛋白酶（ｍａｔｒｉｘｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅｓ，ＭＭＰｓ）是一族依赖Ｚｎ离子降解ＥＣＭ成分的水解蛋白．目前为止该家族肝
Liver fibrosis is a pathological disorder caused by excessive deposition of extracellular matrix (ECM) components of type I and type III collagen. Matrix metalloproteinases (MMPs) are a family of hydrolyzed proteins that rely on Zn ion to degrade ECM components. So far the family liver