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目的：为了观察去卵巢雌鼠骨质疏松症模型骨代谢生化特点。方法：应用１１月龄雌鼠去卵巢方法建立骨质疏松症模型，取血、尿标本检测。结果：去卵巢雌鼠与假手术组比较，血ＡＬＰ、ＢＧＰ及尿Ｃａ、ＨｏＰ、Ｃａ／Ｃｒ、ＨｏＰ／Ｃｒ均明显升高（Ｐ＜ ０．０１）。结论：去卵巢雌鼠骨形成和骨吸收都明显加快，符合绝经后高转换型骨质疏松症的生化特点。
Objective: To observe the biochemical characteristics of bone metabolism in osteoporosis model of ovariectomized female rats. Methods: Osteoporosis model was established by ovariectomized female 11-month-old females and blood and urine samples were collected. Results: Compared with the sham operation group, the levels of ALP, BGP, urinary Ca, HoP, Ca / Cr and HoP / Cr in ovariectomized female rats increased significantly (P <0.01). Conclusion: The bone formation and bone resorption of ovariectomized female rats both evidently accelerated, which is in line with the biochemical characteristics of high conversion osteoporosis after menopause.