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在人类基因组中,G蛋白偶联受体(G protein-coupled receptor,GPCR)是最大的膜蛋白家族,有将近1000个成员。GPCR调控的酶和效应系统包括:AC-AMP系统、PLC-IP3系统、PLA2-花生四烯酸系统以及多种离子通道等[1],其中一部分已被证实具有配体,并已成为明确的药物靶点,剩余部分尚未找到配体,被称为孤儿G蛋白偶联受体(orphan GPCR,oGPCR)。寻找oGPCR的内源性配体,揭示其生理功能及病理意义,对于研究某些疾病
In the human genome, G protein-coupled receptors (GPCRs) are the largest family of membrane proteins with nearly 1,000 members. GPCR-regulated enzyme and effect systems include the AC-AMP system, the PLC-IP3 system, the PLA2-arachidonic acid system, and various ion channels [1], some of which have been shown to have ligands and have become clear Drug targets, the remaining part of the ligand has not been found, known as orphan G protein-coupled receptors (orphan GPCR, oGPCR). Looking for oGPCR endogenous ligand, revealing its physiological function and pathological significance, for the study of certain diseases