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目的 研究血清瘦素水平与 2型糖尿病 (T2DM)合并脑梗死 (CI)的关系。方法 T2DM患者 1 2 8例 (男 65例 ,女 63例 ) ,其中 63例合并CI,应用酶联免疫法测定其血清瘦素水平。结果 (1 )T2DM肥胖者血清瘦素水平高于非肥胖者 (P <0 0 0 1 ) ;(2 )血清瘦素水平在不同性别间差异显著 ,女性高于男性 (P <0 0 0 1 ) ;(3)DM合并CI者血清Leptin水平高于无CI者 (P <0 0 5) ;(4)相关分析发现 ,血清瘦素浓度无论男女均与体重指数 (BMI)、腰围 (Waistcircumference ,WC)、腰臀比 (WHR)、体脂百分比 (BF % )、甘油三酯 (TG)、空腹胰岛素 (FINS)等呈显著相关。用多元逐步回归分析发现 ,BF %、性别、FINS、腰围为影响瘦素最为显著的因素。结论 T2DM合并CI者血清瘦素水平升高 ,血清高瘦素水平与高胰岛素血症的相关性提示 ,瘦素可能在T2DM脑梗死的发病中起一定作用
Objective To study the relationship between serum leptin level and type 2 diabetes mellitus (T2DM) with cerebral infarction (CI). Methods A total of 1288 T2DM patients (65 males and 63 females) were enrolled in this study. Sixty-three of them were combined with CI and serum leptin level was measured by enzyme-linked immunosorbent assay. Results (1) Serum leptin levels were higher in obese T2DM than in non-obese subjects (P <0.01); (2) Serum leptin levels were significantly different among different sexes and higher in females than in males (P <0.01) ); (3) Serum Leptin levels in DM combined with CI were higher than those without CI (P <0.05); (4) Correlation analysis showed that serum leptin concentration was positively correlated with body mass index (BMI), waist circumference WC, WHR, BF%, triglyceride (TG) and fasting insulin (FINS) were significantly correlated. Multiple stepwise regression analysis found that BF%, gender, FINS and waist circumference were the most significant factors affecting leptin. Conclusions Serum leptin level is elevated in patients with T2DM complicated with CI, and the correlation between serum leptin level and hyperinsulinemia suggests that leptin may play a role in the pathogenesis of T2DM with cerebral infarction