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Cerebral angiogenesis in the early stages after cerebral ischemia injury is essential for the recovery of nerve function, in which fetal liver kinase-1 (Flk-1), as a major regulator of vasculogenesis and angiogenesis, plays a very important role. Microvessel density (MVD) was greater in an aged model group compared with the young sham operated group (P < 0.01). MVD and the sum of the lumen area were decreased in the aged group at 1, 3, 6 and 12 days following ischemia/reperfusion (I/R) injury compared with the young model group (P < 0.05 and P < 0.01, respectively). Flk-1 protein and mRNA expression was greater in the aged model group when compared with the young sham operated group (P < 0.01). Flk-1 protein and mRNA expression was lower in the aged group at 1, 3, 6 and 12 days after I/R compared with the young model group (P < 0.01). Flk-1 expression in aged rats attenuated rapidly, but was still maintained at relatively higher levels at 12 days following I/R in younger rats. The results suggest that angiogenesis was weakened after cerebral I/R in aged rats, and the mechanism of which might be correlated with attenuated expression of Flk-1 protein and mRNA.
Cerebral angiogenesis in the early stages after cerebral ischemia injury is essential for the recovery of nerve function, in which fetal liver kinase-1 (Flk-1), as a major regulator of vasculogenesis and angiogenesis, plays a very important role. Microvessel density MVD) was greater in an aged model group compared with the young sham operated group (P <0.01). MVD and the sum of the lumen area were decreased in the aged group at 1, 3, 6 and 12 days following ischemia / reperfusion ( (P <0.05 and P <0.01, respectively). Flk-1 protein and mRNA expression was greater in the aged model group when compared with the young sham operated group (P <0.01) . Flk-1 protein and mRNA expression was lower in the aged group at 1, 3, 6 and 12 days after I / R compared with the young model group (P <0.01). Flk-1 expression in aged rats attenuated rapidly, but was still at relatively higher levels at 12 days following I / R in younger rats. The resu lts suggest that angiogenesis was weakened after cerebral I / R in aged rats, and the mechanism of which might be correlated with attenuated expression of Flk-1 protein and mRNA.