【摘 要】
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Objective We examined alterations in the expression of tumorigenesis-related genes in the pituitary gland of rats exposed to electromagnetic pulses (EMP).Method
【基金项目】
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This study was supported by the Research Fund of the National Natural Science Foundation of China
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Objective We examined alterations in the expression of tumorigenesis-related genes in the pituitary gland of rats exposed to electromagnetic pulses (EMP).Methods The global gene expression profiles of the pituitary gland in EMP-exposed and control groups were detected by cDNA microarray analysis.We then validated and further investigated the reduced expression of two tumorigenesis-related genes,Pten,and Jund,by assessing their mRNA and protein expression by quantitative real-time-PCR,western blotting,and immunohistochemistry in the pituitary gland of rats 6 months after exposure to EMP.Results EMP exposure induced genome-wide gene expression changes in the rat pituitary gland.There was decreased expression of the Pten and Jund mRNAs and proteins in EMP-exposed rats compared with in unexposed control animals.Conclusion EMP exposure alters the expression of tumorigenesis-related genes in the pituitary gland.These tumorigenesis-related genes are potentially involved in the development of pituitary gland tumors in rats.
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