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Ｎ－ＣＷＳ（Ｎｏｃａｒｄｉａｒｕｂｒａｃｅｌｗａｌｓｋｅｌｅｔｏｎ）在每只鼠体内１００～２００μｇ可明显抑制Ｂ１６黑色素瘤细胞在Ｃ５７ＢＬ／６小鼠体内的生长。Ｎ－ＣＷＳ腹腔给药后３ｄ可明显增强小鼠脾脏自然杀伤细胞（ＮＫ）和腹腔巨噬细胞（Ｍφ）的杀伤活性，认为Ｎ－ＣＷＳ的抑制Ｂ１６黑色素瘤作用与其激活小鼠细胞免疫功能有关。体外实验结果表明，当有ＩＦＮ－γ存在的条件下，Ｎ－ＣＷＳ对小鼠腹腔Ｍφ释放ＮＯ及ＴＮＦ都具有显著促进作用，认为这一作用与Ｎ－ＣＷＳ激活小鼠腹腔Ｍφ杀伤Ｂ１６黑色素瘤细胞的机制有关。
N-CWS (Nocardia rubracelwalskeleton) inhibits the growth of B16 melanoma cells in C57BL/6 mice with 100-200 μg in each mouse. Three days after intraperitoneal administration of N-CWS, the killing activity of natural killer cells (NK) and peritoneal macrophages (Mφ) in mice spleen was significantly enhanced. The inhibition of B16 melanoma by N-CWS was associated with its activation of cellular immune function in mice. . The results of in vitro experiments showed that N-CWS had a significant promoting effect on the release of NO and TNF from Mφ in mice in the presence of IFN-γ, which was considered to be associated with N-CWS-activated murine intraperitoneal Mφ killing B16 melanoma. The mechanism of the cell is related.