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目的:观察C4d和C4c在先兆子痈性肾病(PN)肾组织中的分布,探讨PN与体液免疫的关系。方法:应用免疫组化方法,检测14例PN肾活检组织中C4d、C4c及各种免疫球蛋白。设正常肾组织作为对照组。方法:14例PN肾小球C4d和C4c均呈强阳性表达。主要沿血管攀沉积,各种免疫球蛋白少或缺乏;正常肾组有少量C4d沉积在系膜区,其余各种免疫球蛋白无明显沉积。结论:PN时肾小球血管攀C4d及C4c呈强阳性表达,而免疫球蛋白沉积稀少,是其较特异的形态表现;补体C4的激活可能在PN发病机制中起重要作用。
OBJECTIVE: To observe the distribution of C4d and C4c in renal tissue of PN, and to explore the relationship between PN and humoral immunity. Methods: Immunohistochemical method was used to detect C4d, C4c and various immunoglobulins in 14 cases of PN renal biopsy. Normal renal tissue as a control group. Methods: 14 cases of PN glomerular C4d and C4c were strongly positive expression. Mainly along the vascular climbing deposition, a variety of immunoglobulins or lack of a small amount of normal kidney group deposited in the mesangial area C4d, the remaining various immunoglobulins no significant deposition. CONCLUSION: The glomeruli in glomeruli are strongly positive for C4d and C4c in PN, but rare in immunoglobulin. The activation of complement C4 may play an important role in the pathogenesis of PN.