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目的探讨贝那普利对慢性充血性心力衰竭患者左心室及血管内皮功能的影响。方法选取268例慢性充血性心力衰竭,随机分为常规治疗组130例采取常规治疗,贝那普利组138例采取常规治疗联合贝那普利治疗,观察两组治疗前后血管内皮功能测定、左室舒张末内径(LVDd)、左心室射血分数(LVEF)并进行比较。结果两组治疗后FMD、左室舒张末内径、射血分数比较差异有统计学意义(P<0.05)。结论慢性充血性心力衰竭应用贝那普利可以有效的逆转左室重塑,改善左心室功能、血管内皮功能,改善血流动力学,减轻心力衰竭,改善患者的生活质量。
Objective To investigate the effect of benazepril on left ventricular and vascular endothelial function in patients with chronic congestive heart failure. Methods A total of 268 patients with chronic congestive heart failure were randomly divided into routine treatment group (n = 130) and routine treatment (n = 138). The benazepril group (n = 138) was given routine treatment combined with benazepril treatment. The vascular endothelial function was measured before and after treatment Ventricular end-diastolic diameter (LVDd), left ventricular ejection fraction (LVEF) and compared. Results After treatment, FMD, left ventricular end diastolic diameter and ejection fraction were significantly different (P <0.05). Conclusion The application of benazepril in chronic congestive heart failure can effectively reverse left ventricular remodeling, improve left ventricular function, vascular endothelial function, improve hemodynamics, reduce heart failure and improve patients’ quality of life.