采用放射免疫分析（ＲＩＡ）对多发脑梗死模型组大鼠和补肾益脑、活血化瘀中药治疗组血浆内皮素（Ｅｎｄｏｔｈｅｌｉｎ， ＥＴ）进行动态测定，并用水迷宫试验评价其分辨性学习记忆能力。结果表明：多发脑梗死血浆ＥＴ存在先迅速升高，７ｄ 达峰后迅速下降，至１４ｄ 达正常水平的时相变化；补肾益脑、活血化瘀中药组各时期ＥＴ水平均显著低于模型组（ Ｐ＜ ０．０５），且前者学习记忆能力缺损轻于后者（ Ｐ＜ ０．０５）。提示补肾益脑、活血化瘀中药通过降低局部ＥＴ而改善脑梗死的结局 Radioimmunoassay (RIA) was used to measure the plasma Endothelin (ET) level in rats with multiple cerebral infarction and Bushen Yinao and Huoxue Huayu herbs groups, and their learning and memory abilities were assessed by water maze test. The results showed that there was a rapid increase of plasma ET in patients with multiple cerebral infarction and a rapid decrease after reaching the peak on the 7th day, reaching a normal level in 14th day. The ET levels in Bushen Yinao and Huoxue Huayu TCM groups were significantly lower than those in the model group (P <0.05), and the former had less impairment of learning and memory ability than the latter (P <0.05). Prompted Bushenyinao, blood circulation of traditional Chinese medicine by reducing the local ET and improve the outcome of cerebral infarction