胃食管反流病(GERD)是指胃、十二指肠内容物反流人食管引起反酸、烧心等症状,并可导致反流性食管炎以及口咽、喉、气道等食管以外的组织损害。GERD 的发生可能与以下几个因素有关:(1)食管抗反流屏障减弱,包括下食管括约肌(LES)压力极度下降、腹内压增高及频繁出现与吞咽无关的一过性 LES 松弛(TLESR)。(2)食管体部廓清能力减弱。(3)食管粘膜屏障功能障碍。(4)其他,如胃 Gastroesophageal reflux disease (GERD) refers to the stomach, duodenal reflux content of esophageal reflux caused by acid reflux, heartburn and other symptoms, and can lead to reflux esophagitis and the oropharyngeal, laryngeal, airway and other esophageal Tissue damage. The incidence of GERD may be related to several factors: (1) decreased esophageal anti-reflux barrier, including extreme low esophageal sphincter (LES) pressure, increased intra-abdominal pressure, and frequent episodes of transient LES relaxation unrelated to swallowing (TLESR ). (2) Esophageal body clearance ability weakened. (3) Esophageal mucosal barrier dysfunction. (4) Others, such as stomach