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目的观察继发性磺脲类药物失效的2型糖尿病患者应用胰岛素及联合治疗方案的疗效。方法将40例磺脲类药物失效的2型糖尿病患者随机分为胰岛素治疗组20例和联合治疗组20例。治疗12周后,测定两组的血糖、糖化血红蛋白、胰岛素用量及体重,并进行比较。结果两组血糖水平均下降明显,与治疗前相比有显著性差异(P<0.01),但联合治疗组应用胰岛素剂量明显减少(P<0.01),低血糖发生次数及体重增加亦较少(P<0.01)。结论对于口服磺脲类降糖药继发失效的2型糖尿病患者,应用联合治疗可能是一种较安全、有效的选择。
Objective To observe the efficacy of insulin and combination therapy in type 2 diabetic patients with secondary sulfonylurea failure. Methods Forty patients with type 2 diabetes who failed sulfonylurea were randomly divided into insulin treatment group (20 cases) and combination therapy group (20 cases). After 12 weeks of treatment, blood glucose, glycosylated hemoglobin, insulin dosage and body weight were measured and compared. Results The blood glucose levels of both groups decreased significantly (P <0.01), but insulin dosage was significantly decreased (P <0.01), the incidence of hypoglycemia and weight gain were less P <0.01). Conclusions For patients with type 2 diabetes who have secondary failure of oral sulfonylureas, the combination therapy may be a safe and effective option.