论文部分内容阅读
本文阐明不同药物与细胞膜原位作用的分子机制。应用一种非线性光谱-和频振动光谱来研究抗菌药物分子以及氯丙嗪、金刚烷胺和美金刚与电中性和电负性模型细胞膜的相互作用。细胞膜的主要组成部分是膦脂双层膜,因而细胞膜可以被认为是一个界面。从分子层面上原位地在水溶液的环境下阐述了各种材料包括药物分子,纳米材料,高分子,生物大分子与膦脂双层膜作用的机制,本文从非线性光谱-和频振动光谱角度予以综述。揭示了不同药物分子与不同模型细胞膜的不同作用。如一、阐述了抗菌药物分子是怎样破坏模型细胞膜的;二、揭示了氯丙嗪、金刚烷胺和美金刚与不同电性模型细胞膜作用时的相同及不同之处。和频振动光谱已成为一种研究药物分子与细胞膜相互作用的有力工具,可望用于研究中药与细胞膜的相互作用。
This article elucidates the molecular mechanisms of different drugs and membrane in situ effects. A non-linear spectrum-and-frequency vibrational spectroscopy was used to study the interaction of antimicrobial molecules and the membranes of chlorpromazine, amantadine and memantine with the electroneutral and electronegativity models. The major component of the cell membrane is a phospholipid bilayer membrane, so the cell membrane can be thought of as an interface. From the molecular level, the mechanism of various materials including drug molecules, nanomaterials, macromolecules, biological macromolecules and phospholipid bilayer membrane was elaborated in situ under the environment of aqueous solution. In this paper, nonlinear spectroscopy and harmonic vibrational spectroscopy Point of view to be summarized. Revealed the different effects of different drug molecules and different model cell membranes. As one, it expounds how antimicrobial molecules destroy the model cell membrane. Second, it reveals the similarities and differences between chlorpromazine, amantadine and memantine on the cell membranes of different electrical models. The harmonic vibration spectroscopy has become a powerful tool to study the interaction between drug molecules and cell membrane, which is expected to be used to study the interaction between Chinese medicine and cell membrane.