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目的:探讨131I照射宫颈癌细胞后的光谱特征。方法:采集宫颈癌细胞经不同剂量的131I辐照后的红外光谱,比较放射源各剂量组光谱间的差异。结果:10 mCi131I照射组多条谱线变化最为明显,1 542 cm-1谱带在10 mCi照射组红移最多达7 cm-1,1 162 cm-1向低波数频移5 cm-1,2 850 cm-1谱带蓝移4 cm-1,酰胺I带、II带的相对峰强比I1 654/I1 542数值最小。结论:光谱技术是研究宫颈癌治疗效果新的手段,本实验为临床拟定宫颈癌的放疗剂量提供实验依据和参考。
Objective: To investigate the spectral features of 131I irradiated cervical cancer cells. Methods: The infrared spectra of cervical cancer cells after different doses of 131I irradiation were collected, and the differences between the spectra of each dose of radioactive sources were compared. Results: The most obvious change was observed in the spectra of 10 mCi131I irradiation. The bands of 1 542 cm-1 were red shifted up to 7 cm-1 at 10 mCi irradiation and 1,1 162 cm-1 shifted to the low wave number by 5 cm-1, 2 850 cm-1 blue shift 4 cm-1, amide I, II with the relative peak intensity ratio I1 654 / I1 542 minimum value. Conclusion: Spectroscopy is a new method to study the therapeutic effect of cervical cancer. This experiment provides experimental basis and reference for the clinical development of radiation dose of cervical cancer.