论文部分内容阅读
本文用酶联免疫吸附试验（ＥＬＩＳＡ）方法测１１７例失代偿肝硬化患者血清及腹水中粒细胞集落刺激因子（Ｇｒａｎｕｌｏｃｙｔｅ－Ｃｏｌｏｎｙ－ＳｔｉｍｕｌａｔｉｎｇＧＣＳＦ）。结果表明，血清中ＧＣＳＦ阳性率达４５．１６％，腹水中ＧＣＳＦ阳性率为６６．６７％；在原发性腹膜炎中血清ＧＣＳＦ阳性率为１００％（Ｐ＜０．００１），腹水ＧＳＣＦ阳性率为９１．６１％（Ｐ＜０．００１）；在发热及中性粒细胞升高患者血清ＧＣＳＦ阳性率分别为８３．３３％和７３．３８％（Ｐ＜０．００１）。提示ＧＣＳＦ可能是确定细菌感染存在及繁殖与否的一项较敏感的指标，对肝硬化伴发热或中性粒细胞升高者是否应用抗菌素有重要的临床指导意义。
In this study, serum and ascites granulocyte colony stimulating factor (Granulocyte-Colony-Gtimulating G-CSF) in 117 patients with decompensated cirrhosis were detected by enzyme linked immunosorbent assay (ELISA). The results showed that the positive rate of GCSF in serum was 45.16%, the positive rate of GCSF in ascites was 66.67%. The positive rate of GCSF in primary peritonitis was 100% (P <0.001) (91.61%) (P <0.001). The positive rates of GCSF in patients with fever and neutropenia were 83.33% and 73.38% (P <0.001), respectively. It is suggested that GCSF may be a more sensitive index to determine the presence and proliferation of bacterial infection. It is of important clinical significance for the use of antibiotics in patients with cirrhosis and fever or neutrophils.