50～60年代,已经知道胆汁形成并非流体静压的作用,而是需要能量的主动排泌过程,这个过程有胆酸依赖和胆酸非依赖两种形式。70～90年代,弄清了肝细胞是一种有极性、具有分泌功能的上皮细胞,分为基底面(血窦面)和顶(腔)面(胆小管面)。进一步在胆小管膜中分离和纯化了囊性小?.. From the 1950s to the 1960s, it has been known that bile formation is not a function of hydrostatic pressure but requires the active excretion of energy, both in the form of bile acid-dependent and cholic acid-independent. From the 70s to the 90s, it was clarified that the hepatocytes are a kind of polar epithelial cell with secretory function, which is divided into the basal plane (sinusoid) and the top (cavity) surface (ductal surface). Further separation and purification of cystic lesions in the bile duct membrane?