本文报告了3例青霉素所致职业性接触性荨麻疹,其中1例为休克合并荨麻疹,1例为荨麻疹并发过敏性鼻炎。3例均为青霉素注射室的护士。其中1例47岁,工龄26年,既往无青霉素过敏史。1984年6月,她在做青霉素注射时,将一些药液溅到脸上,约20分钟后,脸部肿胀,经注射氢化考的松,肿胀迅速消退。2天后,她在做一次青霉素注射的准备工作10分钟后,出现手部瘙痒,全身性荨麻疹并伴有血压下降,经用激素及抗组胺药治疗后,迅速恢复。此后,脱离接触而无复发。1984年11月,她在注射室内停留1小时未发病,然而将25,000单位的青霉素G溶液涂于她前臂30分钟后,涂抹部位出现风团,几分钟后,另一前 This article reports 3 cases of penicillin-induced occupational contact urticaria, including 1 case of shock combined urticaria, 1 case of urticaria complicated by allergic rhinitis. 3 cases were penicillin injection room nurses. One case of 47 years old, 26 years of service history, no history of penicillin allergy. In 1984 June, she was doing penicillin injection, some liquid splashed on the face, about 20 minutes after the face swelling, after injection of hydrocortisone, swelling quickly subsided. Two days later, after 10 minutes of preparatory work for penicillin injection, she developed hand itching, generalized urticaria accompanied by a drop in blood pressure, and recovered rapidly after treatment with hormone and antihistamine. Since then, without contact without recurrence. In November 1984, she stayed in the injection room for 1 hour without disease, however, after applying 25,000 units of penicillin G solution to her forearm for 30 minutes, the smear appeared on the smear. After a few minutes,