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目的探讨血清降钙素原(PCT)和C反应蛋白(CRP)在社区获得性肺炎(CAP)诊断中的应用价值,旨在为CAP的诊治提供理论参考。方法测定80例正常健康者、80例CAP患者血清PCT、CRP水平,血清PCT采用Brahms快速半定量法(PCT-Q)测定,血清CRP采用自动免疫散射速率比浊法测定。结果 CAP组血清PCT、CRP水平与对照组比较显著升高,相比较有显著性差异(P<0.05)。PCT、CRP的诊断敏感性分别为86.3%和83.8%,二者敏感性比较差异无统计学意义(P>0.05);PCT的特异性为97.5%,显著高于CRP的特异性(83.8%),相比较有显著性差异(P<0.05)。结论血清PCT、CRP的测定对CAP有一定的诊断价值,特别是PCT水平可以作为早期诊断和鉴别CAP的重要指标,值得临床推广应用。
Objective To investigate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of community-acquired pneumonia (CAP), and to provide a theoretical reference for the diagnosis and treatment of CAP. Methods Serum PCT and CRP levels were measured in 80 healthy controls and 80 CAP patients. Serum PCT was assayed by Brahms semi-quantitative assay (PCT-Q). Serum CRP levels were measured by autoimmunoscreening assay. Results The levels of serum PCT and CRP in CAP group were significantly higher than those in control group (P <0.05). The sensitivity of PCT and CRP were 86.3% and 83.8%, respectively. There was no significant difference in sensitivity between the two groups (P> 0.05). The specificity of PCT was 97.5%, which was significantly higher than that of CRP (83.8% , Compared with the significant difference (P <0.05). Conclusions The serum PCT and CRP levels have some diagnostic value for CAP, especially the PCT level can be used as an important index for early diagnosis and differential diagnosis of CAP. It is worthy of clinical application.