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目的探讨红细胞免疫相关表面分子CD35、CD59与疟疾感染的相关性。方法运用流式细胞术对桂西地区少数民族人群587例(年龄20～75岁,平均年龄43.2岁)曾经感染或者正在感染疟疾的患者和560例(年龄20～72岁,平均年龄44.8岁)非易感成年人的红细胞表面分子CD35、CD59表达水平进行检测,并作统计学分析。结果疟疾易感者和非易感者红细胞CD35、CD59平均荧光强度比较差异有统计学意义(P<0.001),疟疾易感者红细胞CD35、CD59分子的平均荧光强度均低于非易感者。结论红细胞表面分子CD35、CD59与疟疾感染有着较为密切的联系,其具体作用机制有待进一步研究。
Objective To investigate the correlation between erythrocyte immune surface molecules CD35 and CD59 and malaria infection. Methods A total of 560 patients (aged 20-72 years, mean age 44.8 years) who had been infected or were infected with malaria were found in 587 cases (aged 20-75 years, mean age 43.2 years) of ethnic minorities in western Guangxi by flow cytometry. Non-susceptible adult erythrocyte surface molecules CD35, CD59 expression levels were detected and for statistical analysis. Results The average fluorescence intensity of CD35 and CD59 in erythrocytes between susceptible and non-susceptible malaria patients was significantly different (P <0.001). The average fluorescence intensity of CD35 and CD59 in erythrocytes of susceptible malaria patients was lower than that of non-susceptible patients. Conclusion Erythrocyte surface molecules CD35 and CD59 have a close relationship with malaria infection. The specific mechanism needs further study.