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目的分析淮安市耐药肺结核高危人群耐药特征,为开展耐药结核病防治工作提供参考依据。方法采用回顾性调查方法,对2013—2014年淮安市耐药肺结核高危人群监测资料进行统计分析。结果淮安市耐药高危人群耐药率45.61%,初、复治患者耐药率分别为33.33%和53.33%;耐多药率23.39%,初、复治患者耐多药率分别为15.15%和28.57%;复治患者耐药率和耐多药率均高于初治患者,差异有统计学意义(P均<0.05);结核分枝杆菌对检测的6种抗结核药品耐药顺位由高到低为异烟肼(INH)35.09%、链霉素(S)26.90%、利福平(RFP)26.32%、氧氟沙星(Ofx)14.04%、乙胺丁醇(EMB)12.28%、卡那霉素(Km)4.09%。结论淮安市耐药肺结核高危人群结核分枝杆菌耐药率和耐多药率均处于较高水平,需进一步加强措施对该部分人群进行耐药监测和防控。
Objective To analyze the drug resistance characteristics of high-risk drug-resistant pulmonary tuberculosis patients in Huaian and to provide a reference for the prevention and control of drug-resistant tuberculosis. Methods A retrospective survey method was used to analyze the data of monitoring at high risk of drug-resistant pulmonary tuberculosis in Huaian from 2013 to 2014. Results The drug resistance rate of high-risk drug-resistant population in Huaian was 45.61%. The rates of drug resistance in primary and re-treatment were 33.33% and 53.33% respectively. The multi-drug resistance rate was 23.39% 28.57% respectively. The rates of drug resistance and multi-drug resistance in retreatment patients were higher than those in the newly diagnosed patients (P <0.05). The drug resistance of Mycobacterium tuberculosis High to low were 35.09% of INH, 26.90% of streptomycin (S), 26.32% of RFP, 14.04% of OFX and 12.28% of ethambutol (EMB) , Kanamycin (Km) 4.09%. Conclusions The drug resistance rate and MDR rate of Mycobacterium tuberculosis in high-risk population of drug-resistant pulmonary tuberculosis in Huaian city are all at a high level. Drug-resistant surveillance and prevention and control of this population should be further strengthened.