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三苯氧胺是抗雌激素类新药。它通过与靶细胞胞质雌激素受体竞争性结合,阻断雌激素效应而发挥抗肿瘤作用。主要通过肝胆系统缓慢地排泄,生物半衰期较长。三苯氧胺适用于女性晚期乳腺癌,目前是停经后晚期乳腺癌的首选药物,对雌激素受体阳性者、停经后病人或老年病人的有效率高。此外,对晚期卵巢癌、宫体癌等实体瘤也有效。服用方便,副反应轻微而安全。
Tamoxifen is an anti-estrogen drug. It competes with the cytoplasmic estrogen receptors of target cells to block the estrogen effect and exert anti-tumor effects. Mainly through the hepatobiliary system slowly excreted, biological half-life longer. Tamoxifen for women with advanced breast cancer, is currently the first choice for postmenopausal advanced breast cancer, estrogen receptor positive, postmenopausal patients or elderly patients with high efficiency. In addition, the advanced ovarian cancer, solid tumors such as Palace body cancer is also effective. Easy to take, minor and safe side effects.