论文部分内容阅读
目的 检测第四人体表皮生长因子受体 (humanepidermal growth factorreceptor 4,HER4)在非小细胞肺癌 (non smallcelllungcancer ,NSCLC)组织中的表达 ,探讨HER4过度表达与NSCLC临床病理特征之间的关系。方法 采用免疫组化法检测 70例NSCLC(鳞癌 43例 ,腺癌 2 7例 )和远离癌灶的 2 0例正常组织中HER4的表达。结果 NSCLC中HER4过度表达率为 91.4% (64 /70 )。HER4过度表达与NSCLC淋巴结转移 (P =0 .0 0 7)、TNM分期 (P =0 .0 11)及术后生存率 (P =0 .0 2 5 8)有密切关系。结论 erbB4是晚期NSCLC生长的一个调控基因 ,干预HER4的过度表达可能是治疗晚期NSCLC的有效方法。
Objective To detect the expression of humanepidermal growth factor receptor 4 (HER4) in non small cell lung cancer (NSCLC) tissues and to explore the relationship between HER4 overexpression and clinicopathological features of NSCLC. Methods Immunohistochemical method was used to detect the expression of HER4 in 70 cases of NSCLC (43 cases of squamous cell carcinoma, 27 cases of adenocarcinoma) and 20 cases of normal tissue far away from carcinoma. Results The overexpression rate of HER4 in NSCLC was 91.4% (64/70). HER4 overexpression was closely related to lymph node metastasis (P = 0.0107), TNM stage (P = 0.011) and postoperative survival (P = 0.0258) in NSCLC. Conclusion erbB4 is a regulatory gene for the growth of advanced NSCLC. Interference of overexpression of HER4 may be an effective method for the treatment of advanced NSCLC.