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本文选择临床分离的6类50株革兰氏阴性杆菌,比较了丁胺卡那霉素分别与呋苄青霉素、氨苄青霉素及唑啉头孢菌素联合后的协同抗菌作用。实验结果表明,丁胺卡那霉素与以上三种β-内酰胺类抗生素有明显协同作用。其中丁胺卡那霉素与呋苄青霉素协同作用最好,协同的菌株占94％,其次为丁胺卡那霉素联合氨苄青霉素,协同占84.4％。丁胺卡那霉素与唑啉头孢菌素的协同作用占77.5％。值得提出的是,丁胺卡那霉素与呋苄青霉素联合对绿脓杆菌有显著协同增效作用。丁胺卡那霉素使呋苄青霉素抗绿脓杆菌作用增效8～250倍,呋苄青霉素可增效丁胺卡那霉素4～16倍。这对临床治疗绿脓杆菌感染具有重要意义。
In this paper, the clinical isolates of 6 strains of Gram-negative bacilli were selected to compare the synergistic antibacterial effect of amikacin with furicillin, ampicillin and azoline cephalosporin. The experimental results show that amikacin and the above three β-lactam antibiotics have a clear synergy. The best combination of amikacin and furcimycin, 94% synergistic strains, followed by amikacin combined ampicillin, concerted 84.4%. The synergistic effect of amikacin and oxazoline cephalosporins accounted for 77.5%. It is worth mentioning that combination of amikacin and furicillin has a significant synergistic effect on Pseudomonas aeruginosa. Amikacin so that the role of furosemide anti-Pseudomonas aeruginosa efficiency of 8 to 250 times, butyracillin can be increased by 4 to 16 times the amikacin. This clinical treatment of Pseudomonas aeruginosa infection is of great significance.