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目的探讨心肌梗塞患者高同型半胱氨酸(HCY)与凝血功能水平的关系。方法选择30例高HCY心肌梗塞住院患者为观察组,38例健康体检者为正常对照组,分别检测观察组及正常对照组HCY、国际凝血酶原比值(PT-INR)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)。结果观察组血清HCY、血浆FIB结果比正常对照组显著增高,差异有统计学意义(P<0.05);血浆PT-INR、APTT较正常对照组时间缩短,差异也有统计学意义(P<0.05)。结论心肌梗塞患者高同型半胱氨酸(HCY)与凝血功能水平的改变有密切的关系,同时检测同型半胱氨酸和凝血功能在心肌梗塞治疗和疗效观察中有着重要的临床意义。
Objective To investigate the relationship between homocysteine (HCY) and coagulation function in patients with myocardial infarction. Methods Thirty patients with hypertensive myocardial infarction (MI) were selected as observation group and 38 healthy controls as normal control group. The levels of HCY, PT-INR, PTEN of activated partial thromboplastin Time (APTT), Fibrinogen (FIB). Results The serum HCY and plasma FIB in observation group were significantly higher than those in normal control group (P <0.05). The plasma PT-INR and APTT were shorter than those in normal control group (P <0.05) . Conclusions The homocysteine (HCY) in patients with myocardial infarction is closely related to the change of coagulation function. It is of important clinical significance to detect homocysteine and coagulation in the treatment of myocardial infarction.