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目的:研究瑞格列奈联合二甲双胍治疗社区2型糖尿病的临床效果,为临床用药提供理论指导。方法:选择2012年5月至2014年5月于我院就诊的92例2型糖尿病患者作为研究对象,随机平均分为观察组和对照组各46例。其中观察组采用瑞格列奈联合二甲双胍治疗,对照组仅采用瑞格列奈治疗。12周后观察并比较两组患者的空腹血糖水平(FPG)、餐后2小时血糖水平(PBG)以及糖化血红蛋白(Hb Alc)的变化情况。同时比较两组患者的治疗有效率。结果:通过对比发现,观察组的治疗有效率明显高于对照组,差异具有统计学意义(p<0.05)。12周后两组患者的FPG、PBG及Hb Lac水平较治疗前均明显下降(p<0.05),但是观察组的下降幅度显著大于对照组,差异具有统计学意义(p<0.05)。讨论:社区2型糖尿病应用瑞格列奈联合二甲双胍治疗的效果较为显著,能有效的降低患者的血糖水平,值得在临床上推广和使用。
Objective: To study the clinical effect of repaglinide and metformin in the treatment of community type 2 diabetes mellitus, and to provide theoretical guidance for clinical use. Methods: A total of 92 patients with type 2 diabetes who were treated in our hospital from May 2012 to May 2014 were randomly divided into observation group (46 cases) and control group (46 cases). The observation group was treated with repaglinide and metformin, while the control group was treated with repaglinide only. After 12 weeks, the fasting blood glucose level (FPG), postprandial blood glucose level (PBG) and hemoglobin A1c (HbAc) level were observed and compared between the two groups. At the same time, the treatment efficiency of the two groups was compared. Results: By comparing the results found that the treatment group was significantly higher than the control group, the difference was statistically significant (p <0.05). After 12 weeks, FPG, PBG and Hb Lac levels in both groups were significantly lower than those before treatment (p <0.05), but the decrease in the observation group was significantly greater than that in the control group, the difference was statistically significant (p <0.05). Discussion: The application of repaglinide in combination with metformin in community type 2 diabetes is more effective. It can effectively reduce the blood sugar level in patients and is worth popularizing and using clinically.