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本文观察了过量蛋氨酸对大鼠大脑额叶、颞叶和下丘脑等脑区以及大鼠肝组织Ｌ－［３５Ｓ］Ｍｅｔ掺入的变化。实验分三组，以基础饲料为对照组，基础饲料添加０．２％ＤＬ一蛋氨酸为适量蛋氨酸组，基础饲料添加２．０％ＤＬ一蛋氨酸为过量蛋氨酸组，饲养２１天，断头杀鼠取上述组织作离体Ｌ－［３５Ｓ］Ｍｅｔ核素标记。结果表明大鼠进食添加２．０ＤＬ一蛋氨酸饲料，鼠脑额叶及颞叶脑区［３５Ｓ］Ｍｅｔ掺入量与对照及适量蛋氨酸组基本一致。在下丘脑区，饲料蛋氨酸水平低，标记的Ｍｅｔ掺入量也低；添加２．０％蛋氨酸组，Ｌ－［３５Ｓ］Ｍｅｔ掺入量明显增加。表明过量蛋氨酸对上述各区脑组织无不良影响。相反，进食过量蛋氨酸，鼠肝Ｌ－［３５Ｓ］Ｍｅｔ掺入量比其他两组明显降低，蛋白质代谢障碍。
In this paper, the effects of excess methionine on the incorporation of L- [35S] Met in rat brain regions such as frontal lobe, temporal lobe and hypothalamus, and rat liver were observed. The experiment was divided into three groups, basal diet as the control group, basal diet supplemented with 0.2% DL-methionine as the right amount of methionine group, basal diet supplemented with 2.0% DL-methionine as excess methionine group, reared for 21 days, The above tissues were taken as L- [35S] Met nuclide labeled in vitro. The results showed that diet supplemented with 2.0DL-methionine fed rats had the same amount of [35S] Met incorporation in the frontal lobe and temporal lobe as compared with the control group and the moderate methionine group. In the hypothalamus area, feed methionine levels were low and labeled Met incorporation was also low; addition of 2.0% methionine significantly increased the incorporation of L- [35S] Met. This indicates that excessive methionine has no adverse effect on the above brain regions. In contrast, the incorporation of L-methionine into rat liver L-35S-Met significantly decreased protein metabolism compared with the other two groups.