自从 1 91 0年 Dale和 Laidlaw发现组胺与变态反应的密切关系以来 ,科学家们一直致力于寻找可以拮抗组胺的物质。从 1 945年合成苯海拉明至今 ,抗组胺药的研制一直没有间断 ,并且取得了巨大的成就。特别是近 1 0余年来 ,新型、高效、低副作用的抗组胺药不断问世 ,使它们成为临 Since Dale and Laidlaw discovered the close relationship between histamine and allergy in 1910, scientists have been searching for substances that can antagonize histamine. Since the synthesis of diphenhydramine from 1945 to the present, the development of antihistamines has been uninterrupted, and has made great achievements. In particular, more than 10 years ago, new, high-efficiency, low-side antihistamines continue to emerge, making them