AIM:To confirm the role of sex-determining region Y-box 7(Sox7) in aspirin-mediated growth inhibition of COX-independent human colorectal cancer cells.METHODS:The cell survival percentage was examined by MTT(Moto-nuclear cell direc cytotoxicity) assay.SOX7 expression was assessed by using reverse transcription-polymerase chain reaction and Western blotting.SB203580 was used to inhibit the p38MAPK signal pathway.SOX7 promoter activity was detected by Luciferase reporter assay.RESULTS:SOX7 was upregulated by aspirin and was involved in aspirin-mediated growth inhibition of SW480 human colorectal cancer cells.The p38MAPK pathway played a role in aspirin-induced SOX7 expression,during which the AP1 transcription factors c-Jun and c-Fos upregulated SOX7 promoter activities.RESULTS:SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells. AIM: To confirm the role of sex-determining region Y-box 7 (Sox7) in aspirin-mediated growth inhibition of COX-independent human colorectal cancer cells. METHODS: The cell survival percentage was examined by MTT (Moto-nuclear cell direc cytotoxicity ) assay. SOX7 expression was assessed by using reverse transcription-polymerase chain reaction and Western blotting. B203580 was used to inhibit the p38 MAPK signal pathway. SOX7 promoter activity was detected by Luciferase reporter assay .RESULTS: SOX7 was upregulated by aspirin and was involved in aspirin-mediated growth inhibition of SW480 human colorectal cancer cells. The p38 MAPK pathway played a role in aspirin-induced SOX7 expression, during which the AP1 transcription factors c-Jun and c-Fos upregulated SOX7 promoter activities. RESULTS: SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells.