论文部分内容阅读
目的:探讨2型糖尿病(T2DM)患者甲状腺肿的发病情况及与心血管疾病的相关性。方法:对235例T2DM患者及对照组103例(健康查体)进行甲状腺B超检查,应用电化学发光法检测血清sTSH水平。结果:T2DM患者甲状腺肿大的发病率为39.6%,高于对照组(26.8%),其中T2DM组女性的发病率高于男性,中年人的发病率高于老年人。血清sTSH水平与年龄呈显著正相关(r=0.867,P=0.000)。T2DM甲状腺肿患者心血管疾病的患病率明显增高。T2DM合并心血管疾病的患者sTSH水平显著升高,Logistic回归分析显示sTSH与心血管疾病显著相关。结论:T2DM患者甲状腺肿患病率增加,特别是老年患者可能会出现亚临床甲状腺功能减退。T2DM患者甲状腺的损害可能进一步加重了糖尿病心血管疾病的发生发展。
Objective: To investigate the incidence of goiter and its relationship with cardiovascular disease in type 2 diabetes mellitus (T2DM). Methods: A total of 235 T2DM patients and 103 healthy controls were examined by thyroid ultrasound. The level of serum sTSH was measured by electrochemiluminescence. Results: The incidence of goiter in T2DM patients was 39.6%, which was higher than that in the control group (26.8%). The incidence of T2DM patients was higher than that of men and the incidence of middle age was higher than that of the elderly. Serum sTSH levels were significantly and positively correlated with age (r = 0.867, P = 0.000). The prevalence of cardiovascular disease in patients with T2DM goiter was significantly higher. In patients with T2DM and cardiovascular disease, the sTSH level was significantly increased. Logistic regression analysis showed that sTSH was significantly associated with cardiovascular disease. Conclusions: The prevalence of goiter in T2DM patients is increased, especially in elderly patients with subclinical hypothyroidism. Thyroid damage in T2DM patients may further aggravate the occurrence and development of diabetic cardiovascular disease.