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目的:探究泮托拉唑钠对急性胰腺炎患者血清肿瘤坏死因子α水平的影响,为急性胰腺炎的诊断和治疗提供临床依据。方法:选取我院收治的120例急性胰腺炎患者,分为观察组和对照组,各60例,给予对照组常规治疗,观察组在对照组的基础上加用泮托拉唑钠静脉滴注,比较两组患者治疗前后的血清TNF-α水平差异。结果:对照组和观察组治疗总有效率分别为95.0%、83.3%,两组治疗效果间的差异具有统计学意义(P<0.05);两组患者治疗前血清TNF-α水平差异无统计学意义(P>0.05),观察组血清TNF-水平明显低于对照组,且差异显著(P<0.01)。结论:应用泮托拉唑钠治疗急性胰腺炎患者的临床效果显著,可有效降低患者血清TNF-α水平,血清TNF-α水平可作为急性胰腺炎诊断或治疗的考察指标,为临床应用提供参考依据。
Objective: To investigate the effect of pantoprazole sodium on the level of serum tumor necrosis factor-α in patients with acute pancreatitis, and to provide a clinical basis for the diagnosis and treatment of acute pancreatitis. Methods: A total of 120 patients with acute pancreatitis admitted to our hospital were divided into observation group and control group, 60 cases in each group. The patients in control group were given routine treatment. The observation group was given intravenous infusion of pantoprazole sodium The differences of serum TNF-α levels before and after treatment were compared between the two groups. Results: The total effective rates of the control group and the observation group were 95.0% and 83.3%, respectively, with significant difference between the two groups (P <0.05). There was no significant difference in serum TNF-α levels between the two groups before treatment (P> 0.05). The level of serum TNF-α in the observation group was significantly lower than that in the control group (P <0.01). Conclusion: The application of pantoprazole sodium in patients with acute pancreatitis has significant clinical effect, which can effectively reduce the level of serum TNF-α and the level of serum TNF-α in acute pancreatitis, which can be used as an index for diagnosis or treatment of acute pancreatitis and provide a reference for clinical application in accordance with.