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目的:评价某院住院患者注射用盐酸纳洛酮的应用情况,并分析其应用合理性。方法:利用“医信通”电子病历质量监控与维护系统,对该院2012年10~12月住院患者医嘱中含注射用盐酸纳洛酮的161份电子病历进行回顾性点评,合理性评价标准为药品说明书、《中国医师药师临床用药指南》。结果:该院注射用盐酸纳洛酮主要用于颅脑损伤患者,为超适应证用药,该用法得到相关文献的支持,但使用剂量和疗程超出推荐范围。结论:该院使用注射用盐酸纳洛酮基本合理,但超适应证用药的现象较普遍,使用该药物治疗颅脑损伤患者时应告知患者,并在循证医学推荐的疗程和剂量范围内使用。
Objective: To evaluate the application of naloxone hydrochloride for inpatients in a hospital and analyze the rationality of its application. Methods: Based on the medical monitoring and maintenance system of electronic medical records, 161 electronic medical records of naloxone hydrochloride for injection in hospital from October to December in 2012 were reviewed retrospectively, and the rationality Evaluation criteria for drug instructions, “Chinese physicians pharmacist clinical guidelines.” Results: Naloxone hydrochloride for injection was mainly used in patients with craniocerebral injury, which was used for the surgeries. The usage was supported by relevant literature, but dosage and course of treatment were beyond the recommended range. CONCLUSIONS: Naloxone hydrochloride for injection is basically reasonable in this hospital, but the phenomenon of using the drug for over-indication is common. The patients should be informed when using the drug in the treatment of patients with craniocerebral injury, and should be used within the recommended courses and dosage of evidence-based medicine .