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目的:探讨氨茶碱结合阿奇霉素治疗咳嗽变异性哮喘(cough variant asthma,CVA)的临床疗效。方法:选取70例符合咳嗽变异性哮喘(CVA)临床诊断的患儿,随机分为治疗组37例和对照组33例。两组均给予口服氨茶碱,在此基础上治疗组给予口服阿奇霉素,对照组给予口服头孢拉定,于治疗后比较两组患儿的治疗效果。结果:治疗组在缓解日间咳嗽,晨起咳嗽,运动后咳嗽消失所需时间明显短于对照组(P<0.05),治疗10日后,气雾诱发咳嗽缓解明显优于对照组(P<0.05)。结论:应用氨茶碱结合阿奇霉素治疗咳嗽变异性哮喘(CVA)取得了显著疗效,在治疗中阿奇霉素主要发挥的是大环内酯类抗生素的气道抗炎作用,可以很好地协助氨茶碱的治疗,且阿奇霉素具有易耐受、药物依从性较好、不良反应少等特点,易被患儿接受,值得推广应用。
Objective: To investigate the clinical efficacy of aminophylline combined with azithromycin in the treatment of cough variant asthma (CVA). Methods: Seventy children with clinical diagnosis of cough variant asthma (CVA) were randomly divided into treatment group (37 cases) and control group (33 cases). Both groups were given oral aminophylline, on the basis of the treatment group given oral azithromycin, the control group was given oral cephradine, after treatment, the treatment effect in both groups were compared. Results: In the treatment group, the cough in the morning, the cough in the morning and the disappearance of cough after exercise were significantly shorter than those in the control group (P <0.05). After 10 days of treatment, the relief of aerosol-induced cough was significantly better than that of the control group (P <0.05 ). Conclusion: Aminophylline combined with azithromycin cough variant asthma (CVA) achieved a significant effect in the treatment of azithromycin major macrolide antibiotics play an airway anti-inflammatory effect, can be a good adjunct to aminophylline Of the treatment, and azithromycin is easy to tolerate, drug compliance is good, less adverse reactions, etc., easily accepted by children, it is worth to promote the application.