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A mild,effective,and selective procedure is reported for the mono N-benzylation and N,N-dibenzylation of primary amines as well as mono N-benzylation of secondary amines using silicasupported copper(I) oxide in water.The silica-supported Cu2O was generated in situ by the reaction of Fehling solution and glucose at 100 °C onto activated silica.The catalyst was filtered,washed with water,and oven-dried,and was characterized by Fourier transform infrared spectroscopy,thermogravimetric analysis,scanning electron microscopy,transmission electron microscopy,and atomic absorption spectroscopy.The prepared Cu2O-SiO2 was found to be thermally stable up to 325 °C.The copper was uniformly distributed onto the surface of the silica,and the mean particle diameter was 7 nm.The catalyst served as a selective heterogenous catalyst for the N-benzylation of primary and secondary amines.The catalyst is recyclable and was used effectively upto fifth run without a significant loss of catalytic activity.Various reaction solvents including water,acetonitrile,and toluene were screened for N-benzylation of amines,and the success of the aqueous system highlights the low environmental impact of the procedure.
A mild, effective, and selective procedure is reported for the mono N-benzylation and N, N-dibenzylation of primary amines as well as mono N-benzylation of secondary amines using silicasupported copper (I) oxide in water. The silica-supported Cu2O was generated in situ by the reaction of Fehling solution and glucose at 100 ° C onto activated silica. The catalyst was filtered, washed with water, and oven-dried, and was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, and atomic absorption spectroscopy. prepared Cu2O-SiO2 was found to be thermally stable up to 325 ° C. The copper was uniformly distributed onto the surface of the silica, and the mean particle diameter was 7 nm. The catalyst served as a selective heterogenous catalyst for the N-benzylation of primary and secondary amines. The catalyst is recyclable and was used effectively up to fifth run without a significant loss of catalytic activity. V arious reaction solvents including water, acetonitrile, and toluene were screened for N-benzylation of amines, and the success of the aqueous system highlights the low environmental impact of the procedure.