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1980年Furchgott和Zawadzki首先证明内源性松弛因子(endothelium derived relaxing factor,EDRF)对离体主动脉张力有重要影响,1987年研究发现,EDRF就是一氧化氮(nitric oxide,NO)或其衍化物。NO作为一种新型信号分子调节着内皮细胞、平滑肌细胞和神经细胞等功能,参与组织炎症及损伤,在呼吸、循环和免疫等多系统疾病的病理生理过程中起着重要作用。NO已经成为目前医学研究的热门领域,并受到人们的高度重视。现就NO在支气管哮喘发病机制中的作用做一回顾总结分析。
In 1980 Furchgott and Zawadzki first demonstrated that endothelium derived relaxing factor (EDRF) has an important effect on isolated aortic tensility. In 1987, EDRF was found to be nitric oxide (NO) or its derivative . As a novel signaling molecule, NO regulates the function of endothelial cells, smooth muscle cells and nerve cells, plays an important role in tissue inflammation and injury, and plays an important role in the pathophysiology of multiple diseases such as respiration, circulation and immunity. NO has become a hot area in medical research at present, and it is highly valued by people. Now on the role of NO in the pathogenesis of bronchial asthma to do a review summary analysis.