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目的观察植入用5-FU缓释剂对胃癌的疗效并与常规5-FU全身化疗作对比。方法将我院1999年12月～2005年12月收治的85例胃癌手术病人分为3组,即单纯局部化疗组、单纯全身化疗组和联合化疗组。观察各组总生存率和每组早、中期肿瘤生存率及晚期肿瘤生存率,并观察每组病人化疗期间的生存质量和化疗毒副反应。结果单纯局部化疗组化疗毒副作用低,生活质量高。局部化疗组5年生存率高于全身化疗组但低于联合化疗组;将早、中期和晚期病人分开统计后发现,对早、中期胃癌,单纯局部化疗组与联合化疗组两者无统计学差异,均优于单纯全身化疗组;对晚期胃癌联合化疗效果最好。结论局部应用5-FU缓释颗粒具有疗效高、毒副作用小、对病人生活质量影响小等优势。对于早、中期胃癌病人,单纯局部缓释化疗即可;对于晚期病人,主张局部缓释化疗与全身化疗联合使用。
Objective To observe the curative effect of 5-FU sustained-release agent on gastric cancer and compare with conventional 5-FU systemic chemotherapy. Methods Eighty-five patients with gastric cancer treated in our hospital from December 1999 to December 2005 were divided into three groups: simple local chemotherapy group, simple systemic chemotherapy group and combination chemotherapy group. The overall survival rate, early and mid-term tumor survival rate and late-stage tumor survival rate of each group were observed. The quality of life and the side effects of chemotherapy during each chemotherapy were observed. The results of chemotherapy alone local chemotherapy side effects, high quality of life. The 5-year survival rate of the local chemotherapy group was higher than that of the systemic chemotherapy group but lower than that of the combination chemotherapy group. Statistical analysis of early, middle and late patients showed no statistical difference between the two groups in early gastric cancer, simple local chemotherapy group and combined chemotherapy group Differences were better than simple systemic chemotherapy group; the best effect of combined chemotherapy for advanced gastric cancer. Conclusion Topical application of 5-FU sustained-release granules has the advantages of high curative effect, small toxic and side effects and little impact on the quality of life of patients. For early and mid-term gastric cancer patients, simply local slow release chemotherapy can be; for advanced patients, advocate the combination of local slow-release chemotherapy and systemic chemotherapy.