粉防己碱(Ⅰ)的钠氨还原裂解可得结构简化物O-甲基杏黄罂粟碱(Ⅱ)和N-甲基乌药碱(Ⅲ)。在分离酚性组分(Ⅲ)时得裂解副产物(Ⅳ),经波谱数据(UV,IR,MS,~1HNMR)和化学合成法确证化合物(Ⅳ)为(+)4′-O-甲基-N-甲基异乌药碱,该副产物的分离鉴别对利用此类反应确定双苄基异喹啉化合物结构有一定的参考作用。 The sodium ammonia reduction cleavage of tetrandrine (I) results in the structurally simplified O-methyl apricot yellow papaverine (II) and N-methylcoclaurine (III). The pyrolysis by-product (IV) was obtained when the phenolic component (III) was separated, and the compound (IV) was identified as (+)4’-O-A by spectroscopic data (UV, IR, MS, ~1HNMR) and chemical synthesis. The separation of this byproduct from the base-N-methylisocoagulbase has certain reference effects for determining the structure of the bis-benzylisoquinoline compound using such reactions.