小球毛细血管内压升高是肥胖患者肾小球受损的主要危险因素,它们不仅直接损害肾小球毛细血管袢内皮细胞,而且促使系膜细胞过度产生细胞因子(如转化生长因子β等);致使系膜基质降解减少,并引起细胞间粘附分子产生等等。此外,与肥胖相关的高脂血症、高胰岛素血症、肾素-血管紧张 Increased capillary pressure is a major risk factor for glomerular damage in obese patients. They not only directly damage glomerular capillary endothelial cells but also induce overproduction of cytokines by mesangial cells (eg, transforming growth factor beta ); Resulting in reduced degradation of mesangial matrix, and cause intercellular adhesion molecule generation and so on. In addition, obesity-related hyperlipidemia, hyperinsulinemia, renin-vascular tone