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Forty-eight New Zealand rabbits were divided into normal group(n=18),control group(n=18)andChinese herbs treatment group(n=12)randomly.The rabbits in the normal group receivedsham-operation,and the OA model was established by Hulth’s method.All the rabbits in the treatmentgroup were given Bushen Huoxue Decoction(补肾活血汤)from the 6th week after the operation.At 6th,8th and 12th week after the operation,the NO concentrations of the serum,joint cartilage and synoviumwere examined.Results:Indicated that the NO concentrations of the serum,joint cartilage and synoviumin the control group were all significantly higher than those in the normal group,with the joint cartilagemore obvious(P<0.05).In the Chinese herbs treatment group the NO concentrations in all the partsobviously decreased as compared with the control group(P<0.05).It is suggested that Bushen HuoxueDecoction decrease the levels of NO in the serum,synovium and joint cartilage in the OA rabbit.
Forty-eight New Zealand rabbits were divided into normal group(n=18),control group(n=18)andChinese herbs treatment group(n=12)randomly.The rabbits in the normal group receivedsham-operation,and the OA model was Established by Hulth’s method.All the rabbits in the treatment group were given Bushen Huoxue Decoction(from Bushen Huoxue Decoction) from the 6th week after the operation.At 6th,8th and 12th week after the operation,the NO concentrations of the serum,joint cartilage and Synoviumwere examined.Results:Indicated that the NO concentrations of the serum,joint cartilage and synoviumin the control group were all significantly higher than those in the normal group, with the joint cartilagemore obvious (P<0.05).In the Chinese herbs treatment group the NO concentrations in all the partsobviously decreased as compared with the control group (P<0.05). It is suggested that Bushen Huoxue Decoction decrease the levels of NO in the serum, synovium and joint cartilage in the OA rabbit.