目的:通过研究补脑膏对血管性认知功能障碍大鼠学习记忆功能、海马谷氨酸和血浆β-内啡肽含量的影响,探讨补脑膏改善VCI大鼠认知障碍的机制。方法:采用反复夹闭双侧颈总动脉结合腹腔注射硝普钠降低血压改良法制备拟血管性认知障碍大鼠模型,检测大鼠学习能力及脑组织中Glu的含量及血浆β-EP的含量。结果:补脑膏大剂量组能明显缩短大鼠受电击后的反应期,降低脑组织中Glu含量,升高血浆中β-EP含量。结论:补脑膏大剂量组有改善血管性认知障碍大鼠认知障碍的作用,其作用与减少脑内Glu含量,升高血浆中β-EP含量有关。 OBJECTIVE: To study the effect of Bu-Nao-Ointment on learning and memory function, hippocampal glutamate and plasma β-endorphin in rats with vascular cognitive impairment, and to explore the mechanism of Bu-Nao Gao on improving cognitive impairment in VCI rats. METHODS: A rat model of vascular cognition impairment was prepared by repeatedly clipping bilateral common carotid artery combined with intraperitoneal injection of sodium nitroprusside to improve blood pressure. The rats’ learning ability and Glu content in brain tissue and plasma β-EP were measured. content. RESULTS: Bunao ointment large-dose group significantly shortened the response period after rats were shocked, reduced the Glu content in brain tissue and increased the plasma β-EP content. Conclusion: Bunao ointment high-dose group can improve the cognitive impairment of vascular cognitive impairment in rats, and its effect is related to the decrease of Glu content in brain and the increase of β-EP content in plasma.