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目的观察茵栀黄颗粒联合光疗治疗高胆红素血症患儿的治疗效果。方法 226例高胆红素血症患儿随机分为观察组114例和对照组112例。2组均给予蓝光照射治疗(光疗),每天照射12h,连续3d,观察组同时给予茵栀黄颗粒1.5g/次,2次/d,口服;对照组同时给予苯巴比妥5mg/(kg.d),2次/d,口服。治疗5d后评定2组治疗效果,并比较2组治疗前及治疗5d后血清总胆红素(total serum bilirubin,TSB)水平。结果观察组总有效率100%高于对照组93.75%(P<0.05);2组治疗后TSB水平均较治疗前下降(P<0.05),观察组下降优于对照组(P<0.05)。结论茵栀黄颗粒联合光疗治疗高胆红素血症效果优于苯巴比妥联合光疗的治疗效果。
Objective To observe the therapeutic effect of Yinzhihuang granule combined with phototherapy on children with hyperbilirubinemia. Methods A total of 226 children with hyperbilirubinaemia were randomly divided into observation group (114 cases) and control group (112 cases). Both groups were given blue light irradiation (light therapy), 12h daily for 3 days, the observation group was given Yinzhihuang granule 1.5g / time, twice daily, orally; while the control group was given phenobarbital 5mg / (kg .d), 2 times / d, orally. After 5 days of treatment, the therapeutic effects of two groups were evaluated, and the levels of serum total bilirubin (TSB) before treatment and after 5 days of treatment were compared between the two groups. Results The total effective rate in the observation group was 100% higher than that in the control group (93.75%) (P <0.05). The TSB levels of the two groups were significantly lower than those before treatment (P <0.05). Conclusion Yinzhihuang granule combined with phototherapy is superior to phenobarbital phototherapy in treating hyperbilirubinemia.