人乳头瘤病毒(human papillomavirus HPV)是一类具有严格宿主范围和组织特异性的DNA病毒,目前已发现100多型。已有的研究表明,90％宫颈癌与HPV感染相关,其中50％的宫颈癌与HPV16感染有关,在成人中HPV16感染率达20％。因此,宫颈癌疫苗的研究主要集中在HPV16型。宫颈癌在全球妇女癌症死因中占第二位,在某些发展中国家甚至居首位。我国每年死于 Human papillomavirus (HPV) is a type of DNA virus with strict host range and tissue specificity. More than 100 types have been found so far. Some studies have shown that 90% of cervical cancer and HPV infection, of which 50% of cervical cancer and HPV16 infection, HPV16 infection rate of 20% in adults. Therefore, the study of cervical cancer vaccine mainly focused on HPV16 type. Cervical cancer ranks second in the global cause of cancer among women and even ranks first in some developing countries. My country dies each year